26 questions of conscience for doctors – with greetings from Jan Bonte

Jan Bonte zet de problemen met de vaccins op een vakkundig rijtje in vraagvorm, veelal voorzien van een leessuggestie. Hij vraagt om het draadje te delen. Bij deze. Het is een indrukwekkende reeks rode vlaggen, al moet ik erkennen dat het mij als leek niet altijd meteen duidelijk is in hoeveel procent van de gevallen een beschreven reactie eigenlijk voorkomt. Je leest soms de vreselijkste dingen en die blijken dan een hoge zeldzaamheid of zelfs een unicum te zijn. Dat neemt niet weg dat de coronavaccins alle records verbreken. En dan te bedenken: wereldwijd integraal uitgerold aan complete bevolkingen - terwijl voorbereidingen worden getroffen voor de kindermoordcampagne. Want het staat vast dat er meer kinderen vroegtijdig zullen overlijden aan de vaccinaties dan Covid had kunnen bewerkstelligen, zeker de omikronvariant. "Ze doen het voor een ander".

The Stinging Bumblebee

Unfortunately,@huisdoktertimnot on my comments. That's a shame, because I want to start the substantive discussion. So I ask Tim a number of questions. #lockdown#persconferentie#vaccinatieplicht

Original antigenic sin: A comprehensive review - PubMedThe concept of "original antigenic sin" was first proposed by Thomas Francis, Jr. in 1960. This phenomenon has the potential to rewrite what we understand about how the immune system responds to infec…https://pubmed.ncbi.nlm.nih.gov/28479213/

This is a very good article that I read several months ago.

We agree that you can be assisted by whoever you want. Whether that is@MarionKoopmansor@NickiVerweij.
Also@shossontwitsand@martijnmollersare welcome.

Fair is fair, isn't it?

Question 1: That's a no-brainer. I have already given the answer: how long is the follow-up in the only study into the efficacy of the booster?

Question 2: Again, I have already given the answer: which variant was dominant in this study?nejm.org/doi/full/10.10...

Question 3: wat houdt het begrip 'antigenic sin' in?

Question 4: is this a hypothetical concept or are there already strong indications of its existence, for example in influenza or dengue?

BNT162b2 Vaccine Booster and Mortality Due to Covid-19 | NEJMOriginal Article from The New England Journal of Medicine — BNT162b2 Vaccine Booster and Mortality Due to Covid-19https://www.nejm.org/doi/full/10.1056/NEJMoa2115624

Question 5: wat houdt het begrip 'titer' in, hetgeen over het algemeen de gebruikte maat is voor antistoffen?

Question 6: if the titer of antibodies rises, does the amount increase, or do they bind more strongly to the target?
Or perhaps both?

Question 7: in het geval van een booster - de derde dosis - die leidt tot een hogere titer van de antilichamen, wat neemt dan het meeste toe?

De hoeveelheid antilichamen of de affiniteit - ofwel de sterkte van de binding?

What is good titer in the case of antibodies?Read 3 answers by scientists to the question asked by Zulfaquar Ahmad Arfi on Nov 29, 2014https://www.researchgate.net/post/What-is-good-titer-in-the-case-of-antibodies

Question 8: I forgot for a moment: what do we know about the safety of giving the booster? Do you have relevant scientific literature that answers that?

I would sincerely like to receive it from you.

Question 9: there are neutralizing and non-neutralizing antibodies. When it comes to neutralizing antibodies, which property is the most important: affinity or quantity?

Question 10: in het vervolg hierop: na een primaire infectie met een ziekteverwekker... ...ondergaan B-cellen - de producenten van de antistoffen - een proces van rijping in de 'germinal center' van de lymfklieren.

What is this process called and how does it work?

GERMINAL CENTER B CELL DYNAMICSGerminal centers (GCs) are the site of antibody diversification and affinity maturation, and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in ...https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5123673/

Question 11: is this process the same in the case of vaccination against SARS-CoV-2 virus compared to the primary infection of the virus?
And suppose the immune system does manage to adapt its response to the #omikronvariant. What are the chances that the old variants will become dominant again? So the alpha, the beta and the delta variant? And what are the chances that new variants will emerge that also avoid the changed vaccines?

https://www.nejm.org/doi/full/10.1056/nejmc2031364

Question 12: In hoeverre is dit proces belangrijk bij het vormen van het 'geheugen' van het immuunsysteem?

biorxiv.org/content/10.110...

Question 13: Now suppose that when giving the booster the amount of the antibodies does increase but not the affinity?

How long does it take for the amount of antibodies to drop so much that the amount is too little again?

Question 14: We know from the first laboratory studies that antibodies bind less well to the#Omikronvariant.

What consequences does that have for the duration of the protection provided by the booster?

Question 15: If#PfizerBioNtechmodifying their mRNA so that they look more like the spike protein of the#OmikronVariant, does the immune system also manage to adapt its response to this variant?

Original antigenic sin: A comprehensive review - PubMedThe concept of "original antigenic sin" was first proposed by Thomas Francis, Jr. in 1960. This phenomenon has the potential to rewrite what we understand about how the immune system responds to infec…https://pubmed.ncbi.nlm.nih.gov/28479213/

Question 16: Suppose that doesn't work.

The immune system continues as before, producing the same antibodies that were optimal for the D614G variant and the alpha variant but not for the delta and omicron variants?What does that mean for the ratio of neutralizing and non-neutralizing antibodies?

Question 17: what could this change in the relationship lead to?

Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike proteinThe spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics aimed at bringing COVID-19 under control. Such a narrow molecul...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250780

Question 18: hoe denken jullie over deze studie?

Deze laat een correlatie zien tussen 'antibody resistence' en 'vaccine resistence' enerzijds, en de vaccinatiegraad anderzijds.

Mechanisms of SARS-CoV-2 Evolution Revealing Vaccine-Resistant Mutations in Europe and AmericaThe importance of understanding SARS-CoV-2 evolution cannot be overlooked. Recent studies confirm that natural selection is the dominating mechanism of SARS-CoV-2 evolution, which favors mutations tha…https://pubs.acs.org/doi/10.1021/acs.jpclett.1c03380

Het Rijksvaccinatieprogramma wordt uitgevoerd bij mensen met een perfect werkend immuunsysteem, door middel van (vrijwel volledig) steriliserende vaccins en in tijden van een lage infectiedruk. Eens? Nu geven we 'lekke' vaccins, aan mensen met voor een groot deel matig werkend immuunsysteem, in een periode van een hoge infectiedruk.

Question 19: does that make a difference? Or does it not matter?

Question 20: is there a risk in the possibility that people will run into the actual infection after the first shot, when immunity has not yet been fully built up? In the period when they have a relative suppression of the immune system?

Question 21: zijn jullie bekend met de mogelijke gevaren van 'leaky vaccines'?

I know, people are not chickens, although I have had some doubts about that lately: head, without and clucking.

Imperfect Vaccination Can Enhance the Transmission of Highly Virulent PathogensA study using Marek's disease virus in poultry shows that by reducing natural selection against highly virulent strains, imperfect vaccination enables the spread of viral strains that would otherwise …https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002198

Question 22: Could this process also occur in humans as a result of the use of leaky vaccines?

Or do you think this is impossible?

medrxiv.org/content/10.110...

Question 23: Since we know that the risk of myocarditis in boys and young men increases significantly with the second dose compared to the first dose.

How many boosters do you dare to give your own children?

academic.oup.com/cid/advance-ar...

Question 24: When will this pandemic end?

The end of the pandemic will not be televisedDashboards of pandemic statistics have dominated screens and helped to track covid-19, but David Robertson and Peter Doshi explain why they might not be enough to define its end As the year 2021 sta...https://www.bmj.com/content/375/bmj-2021-068094

Question 25, the last question:

Given the situation we have ended up in, could we have been warned about this? Or should be?

PCR Tests and the Rise of Disease Panic ⋆ Brownstone InstituteDespite the CDC’s own admission that PCR tests “may not indicate the presence of infectious virus," its use to do exactly that in the case of Covid was accepted without question. Worse still, the meas…https://brownstone.org/articles/pcr-tests-and-the-rise-of-disease-panic/

Life is simple. But not that simple. Nog even het verhaal van de 'antigenic sin' prachtig in een schema samengevat:

And here again when presenting the original pathogen to the immune system compared to presenting it to the immune system, the same pathogen with a slightly different coat on.

It's playing with fire. But people prefer to close their eyes.